Your current location:Home > Latest news text

军情解码

Chinese researchers identify target to develop depression drug using traditional ethnic medicine in Yunnan_我的网站

黑色幽默

A | ミラノ・コルティナ五輪フィギュアスケート女子シングルの金メダリスト、アリサ・リュー（20＝米国）が、中国からの誹謗中傷被害に遭っていると、韓国メディア「OSEN」が報じた。【写真】歯ピアスも話題となっているアリサ・リュウ　標的にされたのは、父・アーサー氏が1989年に中国当局が民主化運動を武力弾圧した天安門事件に関わり、亡命した過去を持つことと関係している。

B | 2022年北京五輪前には、中国側の監視対象となっており、リュウは昨年10月に米メディアの取材に対して、その時の驚きを語っていた。

Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia.
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
An illustration of the research. Photo: Screenshot from the website

An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
。　中国人ネットユーザーからは「高難度ジャンプを避け、3回転中心の安全な構成しか選ばない。氷上の本質的な美学とは程遠い」「中国のフィギュア選手がより優れていた」「米国が故郷だと言いながら、中国での知名度向上に中国人インフルエンサーと絡み、中国系米国人の立場を利用している」などの声が上がっているという。中にはリュウのSNSに「体脂肪率は18～22％」と事実無根の数字を持ち出し体型批判の書き込みを行った者もいるとした。